ACH 2C 07 Semester II Organic Chemistry II (3 Credits)
C.O.1: Describe the reactivity, the stereo chemical aspects and
various reactions possible with carbonyl compounds.
UNIT I Reactions of Carbonyl Compounds
Reactivity of carbonyl groups in aldehydes, ketones, carboxylic acids, esters and acid
chlorides with nucleophilic reagents (Carbon, Hydrogen and Nitrogen nucleophiles).
Carbonyl α-substitution reactions:- Keto- enol tautomerism. Reactivity of enols, mechanism
of α-substitution reactions. α-Halogenation of aldehydes, ketons and carboxylic acids. HellVolhard- Zelinski reaction. Acidity of α hydrogen atom- enolate ion formation. Reactivity of
enolate ions. Halogenation of enolate ions- haloform reaction. Alkylation of enolate ions.
Aldol and related reactions, Claisen ester condensation, Darzen reaction, Dieckmann, Perkin
and Prins reactions. Mannich reaction. Alkylation using enamine. Alkylation of carbon
nucleophiles by conjugate addition, Michael reaction, Robinson anulation. The enamine and
imine anion. Phosphorous ylides and Wittig reaction.
- Teacher: Suja T.D FACULTY