UNIT II Multistep Organic Synthesis
Elements of a synthesis (Reaction methods, reagents, catalysts, solvents, protecting groups (Hydroxyl, Amino Carbonyl and Carboxylic acid protecting groups), activating groups, leaving groups, synthones and synthetic equivalents. Types of selectivities (Chemo, Regio and Stereo selectivities). Synthetic Planning illustrated by simple molecules, disconnections and functional group inter conversions. Umpolung reactions and use in synthesis. Retrosynthetic analysis of a complex molecule-a case study.
REFERENCES
1. John McMurry, Organic Chemistry, 5 Ed., 2000 or newer.
2. Stuart Warren, Designing organic synthesis: programmed introduction to the synthon
approach, 1994.
3. The Logic of Chemical Synthesis, E.J. Corey & Xue-Min Cheng, Wiley, 1989.
4. Classics in Total Synthesis, K.C. Nicolaou, E.J. Sorenson, V.C.H., 1996.
5. Organic Synthesis, Michael B. Smith, 2nd Edition, McGraw Hill, 2004.
6. F.A. Carey, R.J. Sundberg-Advanced Organic Chemistry, Plenum.
7. R.O.C. Norman, Principles of Organic Synthesis.
8. R.S. Ward, Selectivity in Organic Synthesis, John Wiley and Sons.
UNIT IV Molecular Recognition and Supramolecular Chemistry
The concept of recognition, host-guest receptor concept, Forces involved in molecular recognition- hydrogen bonding, Pi stacking, van der Walls and hydrophobic interactions and their significances. Superamolecular chemistry-molecular receptors like calixarenes, crown ethers, Cryptands, Cyclophanes, Cyclodextrins in detail. Self-assembly of supramolecular structures. Introductory study of Combinatorial chemistry.
REFERENCES
1. H. Vogtle, Supramolecular Chemistry, John Wiley and Sons
2. H.Dugas, Bioorganic Chemistry, Springer
3. Fenniri, Combinatorial Chemistry Oxford University Press
- Teacher: Dr A R Suresh Babu FACULTY